| Explore the key differences between deterministic and probabilistic Container Closure Integrity Testing (CCIT) methods, with emphasis on sensitivity, repeatability, and reliability. Deterministic methods provide quantitative, reproducible results with a clearly defined detection limit, making them highly reliable for identifying even microscopic leaks. In contrast, probabilistic methods rely on subjective interpretation and indirect indicators, which can lead to variability and inconsistent outcomes. This comparison highlights why deterministic CCIT is increasingly preferred by regulators and manufacturers for accurate package integrity assessment, robust validation, and improved sterility assurance in pharmaceutical and medical device packaging systems. |
