The Importance of Intermediates in Anti-Psychotic Drugs: Paliperidone, Risperidone, and Quetiapine

Introduction

A.R. Life Sciences Pvt. Ltd. stands as a leader in the pharmaceutical manufacturing landscape, specializing in high-quality Active Pharmaceutical Ingredients (APIs) and intermediates. With a commitment to innovation and excellence, the company plays a critical role in producing intermediates for life-saving medications, including anti-psychotic drugs such as Paliperidone, Risperidone, and Quetiapine. These medications are pivotal in managing mental health and psychological disorders, improving the quality of life for millions worldwide.

Understanding Anti-Psychotic Drugs

Anti-psychotic drugs like Paliperidone, Risperidone, and Quetiapine are widely prescribed for treating schizophrenia, bipolar disorder, and other psychiatric conditions. These drugs act on the brain's neurotransmitter systems to stabilize mood, reduce hallucinations, and improve thought processes. The intermediates used in their synthesis are key role for ensuring the efficacy and safety of the final product.

Paliperidone Intermediates

1. CAS No.: 144598-75-4

Chemical Name: 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Molecular Formula: C10H13ClN2O

Molecular Weight: 212.68 g/mol

Chemical Properties: White crystalline powder, soluble in organic solvents.

Physical Properties: Stable under recommended storage conditions.

Therapeutic Action: Used as a precursor in the synthesis of Paliperidone, an extended-release medication for schizophrenia.

2. CAS No.: 149427-57-8

Chemical Name: 9-Hydroxy-Risperidone

Molecular Formula: C23H27FN4O3

Molecular Weight: 426.49 g/mol

Chemical Properties: Off-white powder, soluble in methanol and ethanol.

Therapeutic Action: The active metabolite of Risperidone, contributing to its therapeutic effects.

Risperidone Intermediates

1. CAS No.: 106266-06-2

Chemical Name: 3-(2-Fluorobenzoyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Molecular Formula: C17H17FN2O2

Molecular Weight: 300.33 g/mol

Chemical Properties: White to off-white powder, sensitive to moisture.

Therapeutic Action: Integral in synthesizing Risperidone, a widely used anti-psychotic medication.

2. CAS No.: 119509-95-4

Chemical Name: 3-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine

Molecular Formula: C9H12N2O

Molecular Weight: 164.2 g/mol

Chemical Properties: A key intermediate in producing high-quality Risperidone.

Quetiapine Intermediates

1. CAS No.: 119097-02-8

Chemical Name: Dibenzothiazepine Quetiapine Intermediate

Molecular Formula: C20H25N3O2S

Molecular Weight: 371.5 g/mol

• Chemical Properties: Pale yellow crystalline powder, soluble in organic solvents.
• Therapeutic Action: Used in synthesizing Quetiapine, a medication for bipolar disorder and schizophrenia.

2. CAS No.: 111974-69-7

Chemical Name: 2-(2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol

Molecular Formula: C22H25N3O2S

Molecular Weight: 395.5 g/mol

Chemical Properties: A versatile intermediate for producing high-purity 

Quetiapine.

Benefits and Uses of Paliperidone, Risperidone, and Quetiapine

Paliperidone

Therapeutic Action: Extended-release anti-psychotic used to treat schizophrenia.

Benefits: Enhances compliance with once-daily dosing, reduces symptoms like hallucinations, and stabilizes mood.

Risperidone

Therapeutic Action: Atypical anti-psychotic effective in managing schizophrenia, bipolar mania, and irritability associated with autism.

Benefits: Fewer extrapyramidal side effects compared to older anti-psychotics.

Quetiapine

Therapeutic Action: Effective in treating schizophrenia, bipolar disorder, and major depressive episodes.

Benefits: Minimal side effects on movement disorders, making it suitable for long-term use.

Why Choose A.R. Life Sciences Pvt. Ltd.?

A.R. Life Sciences Pvt. Ltd. is a leading manufacturer and supplier of high-quality intermediates for Paliperidone, Risperidone, and Quetiapine.

• Strict Quality Control: Advanced manufacturing processes to meet global standards.
• Sustainability: Environmentally friendly production methods.
• Timely Delivery: Reliable supply chain for consistent availability.
• Innovation: Leveraging cutting-edge technology to develop superior intermediates.

Conclusion

Intermediates for anti-psychotic medications like Paliperidone, Risperidone, and Quetiapine are the building blocks of mental health therapies. With precise chemical properties and therapeutic actions, these intermediates are crucial in developing medications that transform lives. Trust A.R. Life Sciences Pvt. Ltd. for high-quality pharmaceutical intermediates that contribute to a healthier, more stable world.